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Effectiveness of glucose-lowering medications on cardiovascular outcomes in patients with type 2 diabetes at moderate cardiovascular risk was published in Nature Cardiovascular Research in April 2024
After reduction to Fe 2+ by STEAP3/DCYTB, iron enters the cytoplasm via DMT1, forming the labile iron pool (LIP)
They reported that at the dose of 100 mg/kg oral, and 10 M in-vitro , curculigoside can behave as a preventive action against osteoblastic bone production reduction and bone loss which is connected to the Protein kinase B- Frokhead box protein O1 (AKT-FoxO1) pathway [95]
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