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Significant correlations were found between the ratio of people over 90 years old per 100,000 inhabitants and trace elements, including molybdenum, in soils, drinking water, and rice, which constitute key elements of their natural environment (55)

However, in evaluating the skin parameters, the addition of HA did not improve the results compared with collagen and vitamin C together

Specifically, 2 mM FeSO 4 solution, 360 mg mL 1 safranine solution, 3% (wt%) H 2 O 2 solution, 0.1 M HCl (aq) and G/D-CuP were added to each well in a 96-well plate (n = 3)

The effects on VAS scores were similar between the two subgroups: oral administration subgroup (MD, 1.15