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Degradation rates have not been published for cosmetic formulations specifically, but the general principle from coordination chemistry is that elevated temperature increases ligand dissociation
The operative principle: the concentration should be chosen so that the smallest dose in the schedule is still measurable, not merely so that the largest dose fits
Some users run BPC-157 23 times per year for joint maintenance
It is believed to inhibit the production of melanin, the pigment responsible for skin color, resulting in a lighter complexion
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