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In some patients, treatment planning may include endocrine assessment or management of related metabolic disorders through services such as diabetes treatment

These indirect mechanisms allow for central nervous system modulation without requiring substantial penetration of the blood-brain barrier, though direct human data on CNS distribution of long-acting incretin agonists remain limited

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The agency stated that semaglutide sodium and semaglutide acetate are "different active ingredients than are used in the approved drugs." They are not considered interchangeable with semaglutide base, and there is no evidence demonstrating that salt forms are safe or effective