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6.1 -Cell damage by ROS Pancreatic -cells exhibit a unique vulnerability to OS due to their inherently low expression of antioxidant enzymes (SOD, CAT, and GPx) and their high metabolic activity, which generates substantial ROS under hyperglycemic conditions (Eguchi et al., 2021)
Metoclopramide (5-10 mg) may be considered for short-term use (less than 12 weeks) under close supervision, as it carries a boxed warning for tardive dyskinesia risk with prolonged use
2022;107(4):e17523
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