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How This Works Dihexa is a modified dipeptide-like molecule built from the tyrosine-isoleucine core of angiotensin IV , with both termini capped by hexanoic-acid-derived groups that raise lipophilicity and blunt enzymatic degradation the changes that gave it oral activity and blood-brain-barrier penetration [1]
Alfoldi, P., et al
In osteosarcoma, single-cell sequencing studies have demonstrated that MHC-I molecules are frequently downregulated, and this reduction in tumor immunogenicity constitutes a key mechanism of immune escape (24)
However, ongoing research continues to explore its various potential uses
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