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After 52 weeks, HbA1c was reduced by 0.4% (4 mmol/mol) by vildagliptin and 0.5% (5 mmol/mol) by glimepiride, body weight was slightly reduced by vildagliptin (0.2 kg) but increased by glimepiride (1.89 kg) and there was a 10-fold higher incidence of hypoglycemia in the glimepiride group
Nonesterified free fatty acids enhance the inflammatory response in renal tubules by inducing extracellular ATP release
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In addition to facilitating interactions between islet cells and immune cells, the islet vasculature also sensitizes the beta-cell to the damaging effects of circulating proinflammatory cytokines
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