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New concerns are being raised about its long-term effectiveness, safety, and what happens when people stop taking it
Medications that slow digestion (e.g., opioids, anticholinergic drugs) : Since tirzepatide and semaglutide already slow down the digestive system, combining them with opioids (like oxycodone or morphine) or other drugs that reduce gut motility may cause severe constipation or bloating
This means they don't undergo the same rigorous testing as standard pharmaceuticals
GLP-1s should only be used under medical supervision to ensure safety and proper dosage
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