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(9) Labunets IF, Butenko GM, Khavinson VKh, Magdich LV, et al (2003) (Regulating effect of pineal gland peptides on development of T-lymphocytes in CBA aging mice: role of microenvironment of immune system organs and neuroendocrine factors)

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These interconnected consequences explain why NAD+ decline is associated with virtually every age-related disease cardiovascular disease, neurodegeneration, metabolic syndrome, sarcopenia, and immune senescence all have NAD+ depletion as a contributing mechanism

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