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Senescent cells are cells that have permanently halted their cell cycle ('replicative arrest') but resist apoptosissometimes called 'zombie cells.' They accumulate with age in multiple tissues and secrete a pro-inflammatory cocktail called the Senescence-Associated Secretory Phenotype (SASP), containing IL-6, IL-8, MMP-3, MMP-9, TNF-, and other factors that damage surrounding healthy tissue

Mechanism Summary

Widely recognized as one of the bodys primary intracellular antioxidants, glutathione plays a critical role in cellular redox regulation, oxidative stress response mechanisms, detoxification pathways, and maintenance of biochemical homeostasis

It has been shown that riboflavin therapy can elevate cardiomyocytes SOD activity in diabetic cardiomyopathy state (33)