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In vitro investigation of Dihexa routinely focuses on organotypic hippocampal slice cultures, primary rodent neuronal cultures, and human induced pluripotent stem cell (iPSC)-derived neurons

One aspect of this cellular communication is to alert the immune response when a cell is under stress or in cases of inflammation

In a study conducted in nine healthy young volunteers, the rise of homocysteine during the postprandial period (after a meal) was found to be greater with marginal vitamin B 6 deficiency (mean plasma PLP level of 19 nmol/L) as compared to vitamin B 6 sufficiency (mean PLP level of 49 nmol/L) (36)