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In vitro tumor cell-fibroblast co-culture systems demonstrated that the Notch signaling pathway activates CAFs, with IL-1 identified as an inflammatory trigger for NF-B pathway induction in CAFs [31]
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Yokota, T., Uchihara, T., Kumagai, J., Shiojiri, T., Pang, J.J., Arita, M., Arai, H., Hayashi, M., Kiyosawa, M., Okeda, R., Mizusawa, H., 2000
CRC Crit Rev Plant Sci 40:127146
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