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On one hand, iron accumulation can upregulate the expression of Nav1.1 and Nav1.6 in the cortex and hippocampus, thereby modulating neuronal excitability (52, 53)
First, in the absence of Albumax and drug, PS exposure of erythrocytes slowly increased over time, both in Ringer solution (24-fold increase after 48 h, p =0.0011) and in iRPMI (6.4-fold increase after 48 h, p =0.0068)
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