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In the muscle cortisol reduces the translocation of the insulin-dependent glucose transporter 4 (GLUT4) to the plasma membrane thereby impairing glucose uptake and by activating glycogen synthase kinase-3 suppresses glycogen synthesis and promotes protein degradation (9) ( Table 1 )

Most of the total weight loss happens in the first 6 to 9 months

Levels rise quickly but often fall just as sharply, leaving highs and lows that dont match the bodys natural design

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