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GIPR antagonist effects in mice global loss of Gipr or Glp-1r We next assessed the ability of a mouse GIPR neutralizing antibody 23 (Kb of 5 nmol l 1 , potency for antagonism of GIP-induced cAMP accumulation) to affect HFD-induced weight gain and food intake in lean mice kept at thermoneutrality (28 C), an environmental temperature where potential confounding effects due to differences in metabolic rate are lowest

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After single IM administrations of doses 20, 100, or 500 g/kg, the peak time (T max ) of each dose was 3 min