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The control group received a single intraperitoneal injection of 30% GalN saline solution between 9:00 and 10:00 am at a dose of 1.4 g/kg body weight, and the proline group received a 10% proline solution orally at a dose of 2 g/kg body weight 1 h before GalN administration

1 This barrier system must be selectively permeable to allow for the absorption of water and nutrients while continuously preventing potentially harmful substances from crossing into the body

Pigmentation is determined by melanin, a pigment produced by specialized cells called melanocytes

Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway