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Together, these effects help reduce overall calorie intake in a way that feels natural rather than forced

For manufacturers, this presents a dilemma

The clinical benefit of GLP-1 receptor agonists in KOA should first be understood through a weight-loss-mediated pathway: substantial body-weight reduction may decrease knee joint loading, improve mobility, and make participation in exercise-based rehabilitation more feasible ( The broader drug-development landscape further supports this repositioning