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Although inhibition of PFKFB3 has also been demonstrated to reduce cancer cell proliferation, the concentrations of the PFKFB3 inhibitor 3-(pyridin-3-yl)-1-(pyridin-4-yl)prop-2-en-1-one (3PO) required to achieve this effect were shown to simultaneously reduce vessel integrity and facilitate metastasis (191193)
When membranes function properly, they can efficiently eliminate toxins while protecting cellular contents
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