tirzepatide and heart Cardiovascular outcomes of semaglutide for patients with type 2 diabetes in clinical practice Lilly's Tirzepatide Reduces Heart Failure

doi:10.1111/dom.13979 Frias JP, Davies MJ, Rosenstock J, et al

Additionally, diabetes-related emotional distress and depression symptom severity have been identified as risk factors for medication non-adherence in T2DM [136, 137]

It was found that the use of inhibitors of ferroptosis could reduce cigarette smoke-induced cell death, suggesting that ferroptosis plays an important role in cigarette smoke-induced trophoblast cell death and may contribute to miscarriage (Guan et al., 2022)

Given that the adequacy of glycemic control before randomization can affect the efficacy of the treatment, all participants will be randomly assigned at a ratio of 1:1 to either continue their existing GLP-1 receptor agonist or switch to semaglutide according to their age, BMI, and HbA1c level