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The REDEFINE trials reported gastrointestinal adverse events in 79.6% of CagriSema patients compared to 39.9% in placebo groups

Choice of delivery method depends on individual goals, clinical judgment, and tolerance for administration methods

But if that patient has established cardiovascular disease, the clinical trials tell us clearly that meaningful cardiovascular protection is likely still occurring through vascular, anti-inflammatory, and hemodynamic mechanisms that are not reflected on the scale

Another recent study showed increased calcium accumulation in renal tubular epithelial cells in response to CHAC1 overexpression, which was ameliorated by CHAC1 knockdown (Dong et al., 2025)