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A randomized, placebo-controlled, single and multiple dose study of intravenous thymosin 4 in healthy volunteers
Biochemical and structural characterization of an intramolecular interaction in FOXO3a and its binding with p53
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When these isolated senescence cells were presented with FOXO4-DRI peptide, researchers reported that the peptide appeared to block FOXO4 proteins, allowing p53 to bind with DNA, which led to the nuclear exclusion of p53 and induction of apoptosis of the senescent Leydig cells
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