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If you are not losing weight on GLP-1 therapy , thyroid optimization should be the first thing investigated

By preventing tyrosinase, reducing melanin formation, and offering antioxidant protection, it successfully fights hyperpigmentation

These functions collectively contribute to the structural and functional integrity of neurons and neuroglia (3, 6, 32)

At the index date in GLP-1 RA vs SGLT-2 inhibitor cohort, GLP-1 RA users were generally younger (median age 55 years [25-75 percentile: 45-65] vs 66 years [25-75 percentile: 57-74] more often female (59% vs 36%) and had a higher level of education compared with SGLT-2 inhibitor users (21% vs 15% were within ISCED level 6-8)