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It is contraindicated for patients with hypersensitivity, hypercalcemia, renal impairment, or sarcoidosis

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The FDA states these products are of unknown quality and may be harmful. The FDA has issued warning letters to companies selling compounded retatrutide, stating that these products are unapproved new drugs and misbranded when sold for human use

While individually beneficial, research has shown that the combination creates enhanced effects on blood flow / vasodilation, nitric oxide production, and body composition better than either ingredient can achieve alone