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Pre-existing gastrointestinal disorders, particularly functional dyspepsia or irritable bowel syndrome, appear to predispose patients to more pronounced GI symptoms

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However, in the posterior cortex, CAT activity was reduced in the VPA+LipRSV group compared to the VPA group, indicating that LipRSV treatment may have negatively modulated the enzymes expression or activity, either by attenuating oxidative stress and thus reducing enzymatic defense needs, or through a possible pro-oxidant effect dependent on the region and experimental conditions