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IFN- is responsible for macrophage activation, enhanced antigen presentation, and induction of nitric oxide-mediated killing mechanisms ( Our preclinical studies confirmed the previous findings that the T2DM group has lower levels of IFN- ( Figure 3E ) and TNF- ( Figure 3F ) when compared to healthy individuals

Coll Ferrer MC, Shuvaev VV, Zern BJ, Composto RJ, Muzykantov VR, Eckmann DM

Small molecule inhibitors as tools to scan for active pathways do not conclusively rule out the participation of a signaling mediator if a negative result is obtained (i.e., no inhibition/augmentation of a toxic endpoint)

Enhanced expression of GST genes during HR-type virus resistance has been also observed in several other host-virus combinations