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For IBS-like discomfort more broadly, the 2021 American College of Gastroenterology clinical guideline on IBS made a conditional recommendation against the use of probiotics for the treatment of global IBS symptoms, citing very low quality of evidence and substantial heterogeneity across strains, doses, and outcomes.[6] The ACG position is the strongest authoritative reading available

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With a view to its simplicity, the most recent standards explicitly suggest IF as a practical, useful tool for people with type 2 diabetes (9)

Effects of betaine supplementation on hepatic metabolism of sulfur-containing amino acids in mice