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Eren-Yazicioglu et al., 2021

"One minute he would be crying and asking what was wrong with him, the next he would talk about wanting to take over Los Angeles," she says

This foundational in vivo evidence has driven an expanding research programme using FOXO4-DRI as a molecular tool across multiple tissues and disease contexts

Key distinctions in the evidence: Tesamorelin: licensed in the US, narrowly indicated, established in HIV-related lipodystrophy, with effects that reverse on stopping treatment Retatrutide: investigational, broader metabolic potential, not yet approved anywhere globally Patients and clinicians should interpret early-phase data for retatrutide with appropriate caution