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In clinical trials, participants were assigned to specific dose groups and followed set escalation schedules

Bariatric surgery: Reduces absorptive surface area Bypasses sections of intestine Requires mandatory supplementation GLP-1 therapy: Preserves intestinal anatomy Does not bypass nutrient transporters Alters appetite rather than anatomy The mechanisms differ fundamentally

While costs in other markets may appear lower, the drugs cost relative to existing treatments and potential health expenditure savings from improved health outcomes will determine how health insurers are affected by their increasing use

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