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If a person on tirzepatide develops any of these gastrointestinal complications, they need immediate hospitalization and emergency medical care

Research published in JAMA Dermatology found that participants on biweekly maintenance dosing retained 8085% of peak pigmentation for up to 60 days, compared to 4050% retention in those who discontinued the peptide entirely

However, weight loss results vary from person to person

The drug is primarily cleared through the kidneys and undergoes hepatic metabolism, making it sensitive to changes in kidney function, liver health, and concurrent medications that affect these organs