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Here, we investigate a diverse panel of 12 immunomodulatory drugs as host-directed treatments (HDTs) for TB meningitis utilizing a cross-species framework comprising studies in a mouse model of TB meningitis with clinical endpoints, and parallel mechanistic studies in a newly developed immune-vascularized human brain organoid model of TB meningitis and peripheral blood mononuclear cells (PBMCs) from patients with TB meningitis
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Previous results indicate that TNC is downregulated by GLP-1RA treatment and correlates with incident CVD 43 , suggesting that TNC may act as a mediator, with downregulation contributing to the cardiovascular-protective effects of GLP-1RAs
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