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This idea, called the Carbohydrate-Insulin Model (CIM), is detailed in a paper by Ludwig et al (2021)

Hippocampal microglial activation triggers a neurotoxic-specific astrocyte response and mediates etomidate-induced long-term synaptic inhibition

Furthermore, the activation of EPAC2 stimulates the release of calcium from the endoplasmic reticulum, which raises intracellular calcium levels and promotes exocytosis