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Why GLP-1 Therapy Alone May Be More Effective Long-Term Clinical trials show that semaglutide alone produces weight loss of 1022% of baseline body weight over 68 weeks, with sustained benefits lasting years when the medication is continued
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Mechanism of Action, Safety, and Efficacy Semaglutide exerts its effects through both central and peripheral pathways, replicating and enhancing the physiological actions of endogenous GLP-1 [35]
