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Mechanism of action: melanocortin cAMP/PKA/MITF cascade Presynaptic activation of cutaneous MC1R and central MC3R/MC4R/MC5R PRIMARY PATHWAY MELANOGENESIS MC1R on melanocytes High-affinity binding to the MC1R receptor on epidermal melanocytes
As people lose weight, they also lose the underlying fat that helps plump and fill out the face
When either adjustment is used, the Low Dose remains 1.6 mg and the Elevated Dose remains 4.8 mg regardless of sex
Its recommended to increase the dose gradually (every four weeks) if additional blood sugar management is needed
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