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Elnaggar A, Tsombou FM, Hussain MI, Almehdi AM, Abideen Z, Yong JWH, et al

Int J Mol Sci (2010) 11:45879.10.3390/ijms11020458 30 BulottaSCelanoMLeporeSMMontalciniTPujiaARussoD

Previous studies have reported that sAC acts as a physiological ATP sensor in glucose-responsive cells, with sAC-generated cAMP reflecting intracellular ATP levels (40)

Our model simulations are reflective of the hepatic GSH environment, agreeing with the supra-pharmacological concentrations of doxorubicin required to illicit comparable GSH depletion in the liver 39