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Every day, it's bombarded by things that damage it: UV radiation from the sun, pollution, stress, poor sleep, alcohol, and the natural metabolic processes your body runs just to keep you alive
In addition, some sHSPs, such as HSPB1/HSP27 and HSPB5, can be phosphorylated through kinase pathways, including the p38/MK2 pathway, which may regulate their chaperone activity, cytoskeletal interactions, and involvement in autophagy-related clearance of damaged cellular components (Ungelenk et al., 2016
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Discovery and characteristics of ferroptosis: exploring the potential of ferroptosis in cancer treatment Ferroptosis is a unique regulated cell death mechanism, distinct from traditional cell death pathways such as apoptosis, necrosis, and autophagy [103]
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