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Huang T, Zhang K, Sun L, Xue X, Zhang C, Shu Z, et al
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Brito, of the Mayo Clinic, looked at data from January 1, 2014 to December 31, 2021 on 351,913 patients who started taking either a GLP-1 drug, a sodium-glucose cotransporter 2 inhibitor (SGLT2i) like Jardiance or Farxiga, dipeptidyl peptidase-4 inhibitor (DPP4i) like Januvia and Onglyza, or a sulfonylurea such as Glucotrol
Despite the mechanistic appeal of natural antioxidants, their adverse-effect and long-term safety profiles remain under-reported and under-analysed, representing a major translational barrier
Published binding studies have demonstrated 10-100 fold increased potency compared to native alpha-MSH at the MC1R
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