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PubMed 10971106 Heffernan M
When used as monotherapy or in combination with metformin, the risk of clinically significant hypoglycemia is relatively low, typically less than five percent, due to the glucose-dependent nature of semaglutides insulin secretion
Long term prescription of medications such as the following are likely to increase the cause of, or exacerbate the risk of B12 deficiency - the proton pump inhibitors (esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole), famotidine, ranitidine, metformin, glibenclamide, gliclazide, glimepiride, glipizide, sodium valproate, gabapentin, doxycycline, some oral contraceptives
