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Tirzepatide independently causes a modest heart rate increase, averaging 2-4 beats per minute in the SURMOUNT clinical trials
That said, if you have the ability to exercise at your convenience, there are some factors to consider
They measured subjective sleep quality more than objective sleep quality They subjectively estimated tiredness Sleep structure was not fully characterized by polysomnography in all studies Data analysis suggested some observed changes were due to issues with the placebo group What is promising about these findings is that statistically significant effects were found in such small sample sizes
Elderly people may also be deficient, as the ability to absorb vitamin B12 decreases with age
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