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These observations were corroborated by single-cell calcium imaging studies in slices of arcuate nuclei, demonstrating that GLP-1MK-801 inhibits the NMDA-induced intracellular calcium surge relative to GLP-1 alone (Extended Data Fig
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The expression of tachykinin precursor 1 (TAC1), the gene encoding substance P, was up-regulated when the BP is raised, indicating an involvement of substance P in high BP conditions (84)
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