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Description

This precision challenge is the main drawback of high-concentration formulations for early dose levels

Published in the New England Journal of Medicine (February 2021), the STEP 1 trial enrolled 1,961 adults

116,253,254,255,256 The expression of NLRP3 is induced by NF-B activation, leading to the assembly of a complex with the adaptor protein ASC and procaspase-1

Initial onset during dose increases, gradual improvement with continued treatment, and minimal long-term impact on quality of life for most participants