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Contraindications Given the limited safety data, conservative contraindications would include pregnancy or plans to become pregnant, breastfeeding, age under 18, severe liver or kidney disease, and any condition requiring medications with unknown interaction potential
Medications and alcohol : Long-term use of certain medications like proton pump inhibitors (PPIs) or metformin, and chronic alcohol use, can interfere with B12 absorption
In some cases, people without prior acne suddenly developed severe breakouts after receiving B12 shots
People also tend to start something new when they feel worst, which is when they are most likely to improve anyway
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