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In rats, it may be activated by peripheral signals, such as distension of the stomach that activate the GLP-1expressing neurons of the NTS, 28 and it has also been associated with enteroceptive stress

Here we show that oral administration of the non-calorie sweetener, rare sugar d-allulose (d-psicose), induces GLP-1 release, activates vagal afferent signaling, reduces food intake and promotes glucose tolerance in healthy and obese-diabetic animal models

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They arent appropriate for everyone