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The GLP-1 revolution has transformed weight management, but many users discover that losing 15-20% of body weight comes with unintended consequences, including loss of lean muscle mass that can reach 25-40% of total weight lost

If pain becomes more persistent or shows a neuropathic component, tricyclic antidepressants (such as amitriptyline or nortriptyline) or SNRIs (duloxetine, venlafaxine) may be added to stabilize nerve sensitivity and enhance long-term pain control

The actual injection takes only a few seconds, and any discomfort is typically minimal and brief

Phase 2 trial (NEJM 2023) randomized 338 adults with obesity to retatrutide doses from 1 mg to 12 mg/week