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The total heart rate increase seen with retatrutide (~57 bpm) therefore reflects the combined contribution of both GLP-1 and glucagon receptor activation on cardiac tissue a pharmacological signature unique to this drug class
Some trials reported enhanced physical performance (17) (20) , and improved aerobic capacity and exercise tolerance (32) whereas others yielded mixed results (37) (38) (39)
One reason this happens is that the Big E has a hand in modulating two critical hunger-modulating hormones: ghrelin, which can rev up food intake, and leptin, the satiety (aka fullness) hormone
However, the field is not staying still, and recently published data from the high-dose semaglutide STEP Phase 3 trials ( What is the optimal balance and receptor potency of GLP-1 and glucagon in a long-acting co-agonist, to minimise adverse effects and to optimise efficacy ( Figure 2 )
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