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A common research framing is a defined block (often 812 weeks) followed by an off period, rather than indefinite continuous use a conservative default given the absence of long-term human data

The advantages of GLP-1 agonists include substantial clinical trial data supporting their efficacy and safety, FDA approval for weight management in certain populations, proven results with many users losing 15-20% or more of body weight, and effects on appetite that make caloric restriction feel natural

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