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In a study, a global DNA methylation that is considerably distinctive was identified within sperm obtained from individuals having oligo-astheno-teratozoospermia (OAT) when compared to the controls and showed the said epigenetic abnormalities can reduce human fertility (Reference Giacone, Cannarella and Mongio20)

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however, short-term beef provocation did not cause plasma L-Cn levels fluctuation, which suggested L-Cn as a potential stable plasma biochemical marker ( Supplementary Figures 2C, D )