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Importantly, food intake remained unchanged in treated animals, suggesting the compound's effects relate to energy expenditure pathways rather than appetite

Individuals with Raynauds disease experience exaggerated vascular responses to cold that can cause tissue damage and should avoid cold therapy

2.4 SA--Gal stain SA--Gal staining of cells and tissues was performed using a senescence-associated -galactosidase staining kit (C0602, Beyotime Biotechnology, Shanghai, China), with all procedures strictly following the manufacturers instructions