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While the initial effects may be felt shortly after the injection, B12 levels gradually decline over time, necessitating regular maintenance doses to sustain optimal levels

Vitamin B12 deficiency is far more widespread than you might imagine

124 Despite the number and variety of approved drugs, it is estimated up to 70% of people with major depression receiving evidence-based treatment with antidepressants continue to experience depressive symptoms, and over a third of cases are deemed treatment-resistant after having not responded to two or more drug trials

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