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Those with heart or kidney disease should follow their healthcare provider's specific advice about fluid intake
Diabetes Care, 27(11), 2628-2635
Is the acetate salt of a synthetic cyclic heptapeptide with the sequence cyclo-(Ac-Nle4-cyclo[Asp5-His6-D-Phe7-Arg8-Trp9-Lys10])-NH2, representing a conformationally constrained, metabolically stabilised derivative of the -MSH(4-10) pharmacophore core in which the Asp5 and Lys10 side chains are bridged by a lactam bond to form the cyclic backbone, Nle4 replaces methionine to prevent oxidative inactivation, and D-Phe7 replaces native phenylalanine to confer endopeptidase resistance and stabilise the receptor-binding pharmacophore conformation
They also have cardio-protective effects, reducing the risks of heart attack, stroke, and cardiovascular mortality [6, 7] and may help to reduce substance use disorders (e.g
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