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Haematological responses typically occur within 1-2 weeks, but neurological recovery may take months and can be incomplete if the deficiency has been prolonged

True B12 toxicity symptoms are rare but may include skin reactions, mild gastrointestinal disturbances, and headaches, particularly with injections

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Periorificial dermatitis (small, red, inflamed bumps around the nose, mouth, or eyes) can be one of the first signs of deficiency, developing within three weeks of low intake